Releasable Pegylation

1. Releasable linker technology increases control, eliminates drawbacks

2. Controlled release of original drug allows full potency and is safer 

3. Full biological activity restored 

A library of triggers for customized half-life

Benefits of QuiaPEG’s proprietary technology 

QuiaPEG’s releasable pegylation technology harnesses the benefits of pegylation while eliminating the potential drawbacks. By developing customized scaffolds, it is possible to adjust the half-life at physiological pH of the bond between the peg-chain and the active drug. Alternatively, the release mechanism can be tailor-made to enable enzyme-specific digestion. These controlled processes result in the release of the original, unmodified active substance.

Benefits of pH-dependent release include stable blood concentrations between dose administrations, thus potentially avoiding adverse drug reactions from high drug concentrations immediately after dosing, and an extended dosing interval, increasing patient convenience.

Clinical benefits of releasable pegylation  

  • Controlled release of the unmodified drug allowing full potency
  • Increased dosing interval
  • Stable blood concentrations
  • May qualify for section 505(b)(2) approval pathway

QuiaPEG Pharmaceuticals Holding AB

Virdings Allé 32 B
754 50 Uppsala
+46 (0) 70 693 12 53

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